Myasthenia gravis is a relatively rare disorder that occurs because of the formation of antibodies against certain receptors at the neuromuscular junction of the muscles. The neuromuscular junction is the point at which the nerves meet the muscles.
Myasthenia gravis is considered an autoimmune disorder because the antibodies are formed in response to an abnormal immune system, which is directed at the body’s own, normal tissues causing their destruction. This disease is often associated with abnormalities of the thymus gland. It has been postulated that the above mentioned abnormal immune response arises due to the incorrect signals sent by this gland.
This disease is common in people of all ages. But, it is more common in females below 40 years and in males above 60 years of age.
Factors that can trigger or worsen the symptoms of this disease are given below:
- Bright sunlight
- Undergoing any surgery
- Emotional stress
What are the signs and symptoms of Myasthenia gravis?
The usual initial sign of this ailment is weakness in a specific muscle rather than generalized weakness. Weakness of the muscles around the eyes may also occur, causing ptosis or drooping of the eyelids. This symptom is present in about 50% of patients having this problem. The weakness in the limbs is greater in their proximal part, i.e. nearer to the centre of the body; than in the distal parts, e.g. the fingers.
The weakness is less severe in the morning and aggravates as the day progresses. It also worsens on exertion and is alleviated by taking rest.
The symptoms progress from mild to extremely severe over a few weeks or months, with periods of exacerbations and remissions. Generalized weakness often sets in within 13 months after the onset of the initial signs of this disease.
Some other symptoms of this disease are given below:
- Diplopia (double vision)
- Change in facial expression
- Dysphagia (difficulty in swallowing)
- Unstable or waddling gait
- Shortness of breath
- Difficulty in swallowing
- Difficulty in rising from a seated position
- Difficulty in talking
- Hoarseness of voice
- Difficulty in maintaining a steady gaze
Some tests that can help in diagnosing this illness are given below:
- The levels of Acetylcholine receptor antibodies in blood
- CT scan of the chest
- Nerve conduction studies
Myasthenia gravis medications are used to treat myasthenia gravis. Mestinon is one of the best medications that can help to control the manifestations of this disorder. The main ingredient of Mestinon is Pyridostigmine. It works by affecting the chemicals responsible for the communication between the nerves and the muscles.
How to use Mestinon
Patients should take ten 60 mg tablets of Mestinon per day. They are advised to take the dose with food or milk to avoid its side effects. Before you buy Mestinon contact a doctor for further information about this medicine.
If the symptoms of myasthenia gravis are not controlled, they may aggravate, causing severe paralysis of the respiratory muscles, needing assisted respiration with ventilatory support to sustain life. Hence, it is essential to treat this disease with efficient medicines like Mestinon.